Msresearch Dayhoff

Microsoft Research's Dayhoff — generates novel protein sequences and scores variants using hybrid Mamba+Transformer models trained on the 3.34B-sequence Dayhoff Atlas. Use when users mention Dayhoff by name, want to generate protein sequences from scratch or from a prompt, score mutations / variants / fitness without experimental data, design sequences in a protein family from homologs, scaffold sequences around a motif, or are setting up / running / troubleshooting the Dayhoff prototype locally